The Lexus GX 460, like all Lexus models, is equipped with an array of dynamic safety systems. Vehicle Stability Control (VSC) helps keep the Lexus GX 460 going on its intended course by detecting front- and rear-wheel slide during cornering and attempting to control either condition with a combination of torque intervention and individual wheel braking. Electronic Brake-force Distribution (EBD) utilizes the anti-lock brake system (ABS) and distributes proper brake force between the front and rear wheels according to driving conditions and wheel-load.

Brake Assist (BA) is designed to determine if the driver is attempting emergency braking, and if the driver has not stepped firmly enough on the brake pedal to engage ABS, the system supplements the applied braking power.

The Supplemental Restraint System (SRS) includes a class-leading standard 10 airbags: dual front and side airbags; driver and front passenger knee airbags; second-row seat-mounted side airbags, and roll-sensing side curtain airbags covering all two or three rows. The front airbags are designed to inflate according to collision severity. The roll-sensing side curtain airbags are designed to deploy when a severe tilt angle, roll or lateral G-force is detected.

The optional Pre-Collision System (PCS) can help reduce collision damage. The package includes Dynamic Radar Cruise Control, which uses millimeter-wave radar to measure and help maintain a pre-set distance from a vehicle traveling ahead. The multi-information display within the combination meter will show a car icon with the selected following distance. If, based on a variety of inputs, PCS determines that a collision is unavoidable, the system preemptively retracts the front seat belts and pre-initializes BA so that increased braking will be applied the instant the driver depresses the pedal.

In addition, an available Pre-Collision System with Driver Attention Monitor and Lane Departure Alert (LDA) is now available for the 2010 GX 460. Using two small cameras mounted at the front of the vehicle that work in conjunction with millimeter-wave radar, the system is sensitive enough to detect certain nonmetallic objects. The Driver Monitor System uses a third camera, mounted on the steering column, monitors the orientation of the driver's face.

If the camera detects that it appears the driver is not looking directly ahead for a few seconds or more, and if an obstacle is detected ahead, then it alerts the driver, first with a warning chime and a flashing light. As the car gets closer to the obstacle, PCS can begin to gently apply the brakes on its own.

To help assist the driver in maneuvering around the obstacle, the system reprograms the steering ratio, amplifying the intensity and quickness of the steering response. At the same time, PCS automatically retracts the front seatbelts and prepares the brake system to respond with full force when activated by the driver in anticipation of a possible impact.

LDA alerts the driver of unintentional lane departure by sounding a warning buzzer and displaying an alert. It does not steer the vehicle independently and it requires the driver to maintain active steering control.

New for 2010, active front headrests move up and forward almost instantly in the event of certain lower speed rear-end collisions when the force of the occupant's body is applied to the seat back. Also new, the available Adaptive Front lighting System (AFS), illuminates a turn or curve as the driver steers into it and includes high intensity discharge (HID) headlights. The available Pre-Collision System with Driver Attention Monitor Package includes new Intelligent High Beams with headlamp cleaners automatically adjust the high beams to avoid blinding drivers in oncoming vehicles. The cleaners help ensure optimal headlight performance in all weather conditions.